Abcam, ab200656, Anti-CFH + CFHL1 antibody [EPR17159]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CFHR1 antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17159,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Complement Factor H (CFH) and Complement Factor H-Like 1 (CFHL1) are important proteins involved in the regulation of the complement system. CFH is also known as CFH band and has a molecular mass of approximately 150 kDa. These proteins are mainly expressed in the liver and are present in plasma. CFHL1 is a truncated version of CFH and shares structural similarities with it. Both proteins have an important role in maintaining balance in the immune system.
Biological function summary
CFH and CFHL1 control the activity of the alternative complement pathway by inhibiting the formation of the C3 convertase and promoting the disassembly of the convertase complexes. This process prevents overactivation of the complement system which can otherwise damage host tissues. CFH functions as a cofactor for factor I aiding in the degradation of C3b. Both proteins are not part of a larger complex but interact with other components in the pathway to regulate complement activation.
Pathways
Both CFH and CFHL1 play essential roles in the alternative complement pathway and the regulation of complement cascades. They interact closely with proteins like C3b and factor I to modulate the immune response. This regulation is important for preventing unintentional cellular damage and ensuring proper immune function. CFH particularly ensures that this pathway does not escalate into an inflammatory reaction in healthy tissues.
Defects or deficiencies in CFH or CFHL1 relate to conditions like age-related macular degeneration (AMD) and atypical hemolytic uremic syndrome (aHUS). These diseases link to uncontrolled complement activation and tissue damage. In AMD CFH's interaction with proteins like C3 is important for preventing retinal damage. For aHUS CFH mutations disrupt normal function leading to excessive complement activity and renal injury.