Abcam, ab200664, Anti-Tmem27 antibody [EPR17748]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Tmem27 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Mouse, Rat, Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17748,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-P, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tmem27 also known as collectrin is a type I transmembrane protein with a mass of approximately 46 kDa. It is predominantly expressed in the kidney and pancreas where it localizes mostly at the apical membranes of epithelial cells in renal proximal tubules and pancreatic ducts. Tmem27 engages in processes associated with cell surface expression influencing the behavior of nearby ion channels and transporters.
Biological function summary
The involvement of Tmem27 extends to the regulation of amino acid transport and insulin exocytosis. It associates with the γ-aminobutyric acid type B receptor (GABBR) complex contributing to the modulation of nutrient uptake. Tmem27 influences the processing and trafficking of small neutral amino acids enhancing their absorption across epithelial barriers which is important for maintaining cellular homeostasis and metabolic activities.
Pathways
The function of Tmem27 is significant in the renin-angiotensin system and the insulin signaling pathway. In the renin-angiotensin system Tmem27 operates alongside the angiotensin-converting enzyme (ACE) to precisely regulate blood pressure homeostasis. It also acts within the insulin signaling pathway by modulating insulin secretion potentially working closely with glucose transporter type 4 (GLUT4) to ensure efficient glucose uptake by cells.
Tmem27 has connections to conditions such as diabetes mellitus and kidney disease. Its involvement in insulin secretion links it to diabetes impacting glucose homeostasis when irregularities occur. Tmem27's interactions with angiotensin-converting enzyme can affect blood pressure regulation creating implications for hypertension-related kidney disorders. Understanding these associations highlights the potential of Tmem27 as a therapeutic target in managing these diseases.