Abcam, ab20095, HRP Anti-Treponema pallidum antibody

Size: 500µL
Rabbit Polyclonal Treponema pallidum antibody - conjugated to HRP. Suitable for IHC-P, ICC and reacts with Treponema pallidum samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Conjugation:HRP,
Carrier free:No,
Reacts with:Treponema pallidum,
Applications:ICC, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:Recognises all antigens. Non reactive in RPR assay. Has not been absorbed and may react with related microoragisms.

Product details:
Titer: >1:3,000 (indirect FA). Warning: Use of sodium azide as a preservative will substantially inhibit the enzyme activity of horseradish peroxidase.
Covalently coupled to a highly purified preparation of horseradish peroxidase (RZ>3). Care is taken to ensure adequate conjugation while preserving maximum enzyme activity. Free enzyme is removed. Estimated molar HRP:IgG substitution is 2-3. >95% pure, before conjugation.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.002% Thimerosal (merthiolate)Constituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Treponema pallidum also known as T. pallidum is a spirochete bacterium responsible for syphilis. It is a pathogen with a mass of approximately 1000 to 1500 kilodaltons. This bacterium expresses itself through a complex outer membrane rich in lipoproteins which allows it to evade the host immune response. Treponema pallidum resides primarily in various human tissues and fluids particularly the bloodstream where it can disseminate throughout the body.
Biological function summary
The spirochete bacterium causes systemic infection and can invade multiple organs and systems. As part of a highly invasive entity Treponema pallidum can penetrate the endothelium and interact with host cells promoting persistent infection. It lacks numerous enzymes found in other bacteria which makes it dependent on the host for nutrients complicating its study. The bacterium is adept at avoiding the immune system partly due to its limited surface proteins that are targeted by host defenses.
Pathways
The interaction of Treponema pallidum with host immune pathways involves critical interference with host-pathogen interactions. It affects pathways related to immune evasion influencing the complement system and cytokine signaling. The bacterium influences other proteins like those regulating immune responses resulting in altered host immune functionalities. It exploits these pathways to promote survival and successful infection within the host.
Treponema pallidum causes syphilis a chronic disease characterized by multiple clinical stages including primary secondary and tertiary syphilis. It also has associations with neurosyphilis which affects the nervous system. Treponema pallidum's involvement with these conditions often relates to immune response alterations and inflammation mediated through its impact on proteins involved in immune signaling and neurological systems. Understanding these interactions can facilitate development of effective treatments or preventive measures.