Abcam, ab20128, Anti-BarX2 antibody [BAR X2 8A7/1]

Size: 50µg
Mouse Monoclonal BARX2 antibody. Suitable for ELISA, WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Protein within Human BARX2.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:BAR X2 8A7/1,
Isotype:IgG1,
Light chain type:unknown,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, ELISA, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Protein within Human BARX2. The exact immunogen used to generate this antibody is proprietary information.Q9UMQ3

Product details:
BarX2 is a tumour suppressor gene that encodes for a transcription factor known to regulate transcription of cell adhesion molecules in the mouse.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
BarX2 also known as BarH-like 2 is a transcription factor involved in gene regulation. BarX2 has an estimated mass of around 36 kDa. It initially expresses in various tissues including the central nervous system and the developing limb. BarX2 contains a homeobox domain a DNA-binding region influencing gene expression by interacting with specific DNA sequences. This capability makes it critical in transcriptional regulation involved in developmental processes.
Biological function summary
BarX2 plays a significant role in neuronal differentiation and limb patterning. It functions by controlling the expression of downstream target genes that drive cellular differentiation and growth. BarX2 does not form part of a larger complex but interacts individually with target genes in developmentally active tissues. It affects the expression patterns that lead to specific cell fates especially during embryogenesis.
Pathways
The transcription factor BarX2 integrates into critical pathways like the Wnt signaling and Notch signaling. These pathways are pivotal in regulating cell proliferation differentiation and apoptosis. BarX2 works alongside proteins like beta-catenin in Wnt signaling to influence gene expression changes important for cell fate decisions. In Notch signaling BarX2 modulates the balance between cell proliferation and differentiation essential in developing organs.
BarX2 has connections to oncogenesis and certain developmental defects. Its altered expression or mutation correlates with colorectal cancer impacting the regulation of cell proliferation and apoptosis. BarX2 interacts with proteins such as c-Myc which plays a role in promoting cellular growth and cancer development. Additionally in developmental defects aberrant BarX2 expression links to limb malformations where it influences the expression of genes controlling limb patterning and skeletal formation.