Abcam, ab201693, Anti-PIGK antibody [EPR17843]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PIGK antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 10 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17843,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, Flow Cyt (Intra), WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PIGK also known as phosphatidylinositol glycan anchor biosynthesis class K functions as an essential component of the glycosylphosphatidylinositol (GPI) transamidase complex. This protein carries a mass of approximately 37 kDa. You find PIGK in the endoplasmic reticulum across various cell types where it assists in the post-translational modification processes required for protein anchoring to cell membranes.
Biological function summary
The GPI transamidase complex which includes PIGK facilitates the attachment of proteins to the cell membrane via GPI anchors. This activity is a critical post-translational modification essential for the functionality and localization of these proteins. Within this complex PIGK operates alongside other components such as PIGT and GPAA1 to ensure correct positioning and attachment of GPI-anchored proteins.
Pathways
PIGK contributes to the biosynthesis and remodeling of GPI-anchored proteins impacting the GPI-anchor biosynthesis pathway itself. This pathway plays an integral role in cellular processes that involve anchoring proteins like CD55 and CD59 which are important for membrane dynamics and cell surface interactions. As part of these pathways PIGK's function links closely with other proteins in the remodeling process ensuring proper protein placement and functionality.
PIGK's role in GPI-anchor biosynthesis links it to various inherited GPI deficiencies. A disruption in PIGK function may contribute to neurological symptoms and developmental disorders like hyperphosphatasia with mental retardation syndrome (HPMRS). The connection between PIGK and diseases often involves interactions with other components of the GPI biosynthesis pathway such as PIGA highlighting the significance of PIGK in maintaining cellular and physiological homeostasis.