Abcam, ab201952, Anti-Somatostatin Receptor 3/SSTR3 antibody [7H8E5]

Size: 100µg
Mouse Monoclonal Somatostatin Receptor 3/SSTR3 antibody. Suitable for Flow Cyt, WB and reacts with Human, Rat, Transfected cell lysate - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SSTR3 aa 1-50.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:7H8E5,
Isotype:IgG1,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SSTR3 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.P32745

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified from tissue culture supernatant., Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Somatostatin Receptor 3 (SSTR3) also known as SS3R or SRIF1C is a G-protein-coupled receptor with an estimated mass of around 45 kDa. This receptor specifically binds the peptide hormone somatostatin leading to a variety of intracellular responses. Located primarily in the central nervous system SSTR3 is particularly concentrated in the hypothalamus and hippocampus though it also appears in peripheral tissues like the pancreas and gastrointestinal tract. The receptor transmits signals that involve inhibition of adenylyl cyclase and activation of phosphotyrosine phosphatases.
Biological function summary
SSTR3 plays an important role in inhibiting the release of several other hormones and neurotransmitters like growth hormone and glucagon which helps regulate endocrine and nervous system activities. It functions as part of a complex system that includes other somatostatin receptors. By interacting with these systems SSTR3 influences processes such as cell proliferation neurotransmission and the modulation of cyclic AMP levels. Due to its inhibitory function the receptor helps maintain balance in hormone secretion and neural activity.
Pathways
SSTR3 receptor signaling integrates into the somatostatin signaling pathway an important process in hormone secretion regulation. It works closely with other receptors like SSTR2 together mediating somatostatin effects throughout the body. The receptor is also involved in the MAPK signaling pathway which has roles in cellular responses to various stimuli. These pathways contribute to its ability to modulate growth apoptosis and neuronal signaling.
SSTR3 has associations with neurodegenerative diseases such as Alzheimer’s disease due to its role in the central nervous system and neuroprotection. Changes or dysfunctions in SSTR3 expression can influence the progression of these conditions. The receptor’s interaction with other proteins like amyloid-beta peptide links it to the pathophysiology of Alzheimer’s. Additionally SSTR3 has a role in pituitary adenomas influencing growth hormone secretion patterns. This involves interaction with growth hormone-releasing hormone highlighting its impact on endocrine disorders.