Abcam, ab202419, Anti-SGTB/SGT2 antibody [EPR17183]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SGTB/SGT2 antibody. Suitable for IP, WB, ICC/IF, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR17183,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WB, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SGTB also known as SGT2 is a co-chaperone protein with a molecular weight of approximately 35 kDa. It belongs to the small glutamine-rich tetratricopeptide repeat-containing and β-tubulin folding cofactor family. This protein is expressed in various tissues including the brain and liver. It interacts mechanically with other chaperones by forming complexes with HSP70 and HSP90 assisting in the folding and stabilization of client proteins.
Biological function summary
The co-chaperone activity of SGT2 facilitates essential cellular functions through its interaction with molecular chaperones. This protein plays a significant role in the protein quality control system within the endoplasmic reticulum (ER). SGT2 contributes to the functionality of the ER-associated degradation (ERAD) pathway by recognizing misfolded proteins destined for degradation. Through this action it supports cellular homeostasis and prevents the aggregation of misfolded proteins.
Pathways
SGT2 engages actively in the ERAD and heat shock response pathways. Within these pathways it works closely with chaperones like HSP70 and HSP90 to maintain protein quality control and cellular stress responses. SGT2 regulates the degradation of misfolded proteins which is important in the ERAD pathway for maintaining proteostasis. By coordinating with other co-chaperones SGT2 ensures the transfer of substrates to the ubiquitin-proteasome system therefore facilitating their removal and preventing cellular dysfunction.
SGT2's role in protein degradation links it to neurodegenerative diseases and cancer. In neurodegenerative diseases such as Alzheimer's disease the accumulation of misfolded proteins can result from dysfunctional protein degradation processes where SGT2 plays a role. Similarly alterations in SGT2 function could contribute to cancer as protein misfolding and degradation dysfunctions are often observed in tumor cells. In these disorders SGT2's interaction with chaperones like HSP70 and other components of the degradation pathways may become impaired disrupting cellular function and promoting disease progression.