Abcam, ab202901, Anti-OSTF1 antibody [EP15457]

Size: 100µL
Rabbit Monoclonal OSTF1 antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP15457,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WB, IP, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OSTF1 also known as Osteoclast-Stimulating Factor 1 is an important protein involved in the regulation of bone resorption. It has a molecular weight of approximately 60 kDa. OSTF1 is widely expressed in bone tissues where it influences the activity of osteoclasts. Researchers have identified it as a cytoplasmic protein that plays a role in signaling processes. OSTF1 functions as an adapter protein linking other proteins involved in cellular functions related to bone metabolism.
Biological function summary
OSTF1 interacts with cytoskeleton-associated proteins to enhance osteoclast activity. It coordinates the assembly of protein complexes essential for cell movement and actin cytoskeleton organization. OSTF1 is known to engage in complex formations with proteins such as Src a tyrosine kinase that facilitates its regulatory activities in osteoclasts. This interaction highlights OSTF1's role in the dynamics of cell adhesion and mobility which are important for bone remodeling processes.
Pathways
OSTF1 plays a role in the RANK/RANKL/OPG signaling pathway an important pathway for bone homeostasis. It partners with the Src protein in this pathway influencing osteoclast differentiation and activation. Besides OSTF1 is linked to the integrin signaling pathway through its interactions with cytoskeleton components which is equally significant for cell adhesion and survival. By mediating these interactions OSTF1 helps modulate the balance between formation and breakdown of bone matrix.
OSTF1 has associations with osteoporosis and Paget’s disease of bone. In osteoporosis the deregulation of OSTF1 influences abnormal osteoclast activity leading to increased bone resorption and fragility. In Paget’s disease OSTF1 may interact with other proteins like TNF receptor-associated factor 6 (TRAF6) affecting the excessive breakdown and formation of bone. The involvement of OSTF1 in these conditions makes it a target of interest for therapeutic interventions in bone diseases.