Abcam, ab203072, Anti-GALR2 antibody

Size: 100µL
Rabbit Polyclonal GALR2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GALR2 aa 50-100 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GALR2 aa 50-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.O43603

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GALR2 also known as Galanin receptor type 2 is a G protein-coupled receptor with a molecular mass of around 38 kDa. This receptor is expressed in several tissues including the central nervous system peripheral nervous system and various peripheral organs. GALR2 interacts with the neuropeptide galanin which modulates several physiological functions. The receptor signals through different classes of G proteins leading to the activation of intracellular second messengers.
Biological function summary
GALR2 influences numerous processes essential for maintaining homeostasis. It mediates cellular responses to stress appetite and mood through interaction with its ligand galanin. Though GALR2 does not form part of a larger receptor complex it plays a central role in its signaling pathways. Researchers recognize its function in promoting neurogenesis and modulating neurotransmitter release impacting several neural circuits.
Pathways
GALR2 plays roles in the MAPK/ERK pathway and the PI3K/AKT pathway. These pathways are essential for cell survival differentiation and proliferation. GALR2 interacts closely with other receptors such as GALR1 and GALR3 sharing similar downstream effects while maintaining distinct cellular responses. Such interactions help coordinate various physiological functions like memory and feeding behavior.
GALR2 has associations with depression and epilepsy. The receptor's modulation of mood regulation links it to depressive disorders while its influence on neurotransmitter release affects epilepsy-related pathways. In these conditions GALR2 often works with other galanin receptors particularly GALR1 to mechanisms that underpin neural dysfunction and resilience. Understanding its roles provides insight into potential therapeutic targets for managing these disorders.