Abcam, ab203516, Anti-Bcl2-L-13 antibody [EP10625]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Bcl2-L-13 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP10625,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Bcl2-L-13 also known as Bcl-rambo or BCL2-LIKE 13 is a member of the Bcl-2 protein family with a molecular mass of approximately 55 kDa. This protein is involved in the regulation of apoptosis a process of programmed cell death. Bcl2-L-13 is a membrane protein mainly expressed in the mitochondria but can also be found in other cellular compartments like the endoplasmic reticulum. Its expression levels and activity can vary among different tissues and under different conditions.
Biological function summary
Bcl2-L-13 regulates mitochondrial dynamics and influences the mitochondrial apoptotic machinery. It can act as a pro-apoptotic or anti-apoptotic factor depending on its interactions with other Bcl-2 family proteins. This protein does not work alone but often forms complexes with other Bcl-2 family members to modulate apoptotic pathways. By affecting mitochondrial membrane permeabilization it controls the release of cytochrome c and other pro-apoptotic factors that trigger downstream caspase cascades.
Pathways
Bcl2-L-13 is involved in intrinsic apoptosis signaling and mitochondrial maintenance pathways. It interacts with proteins like Bax and Bak facilitating either protection against apoptosis or promotion of cell death. Additionally Bcl2-L-13 influences crosstalk between the mitochondria and other cellular organelles affecting cell survival and death mechanisms under stress conditions. These interactions play a significant role in maintaining cellular homeostasis.
Bcl2-L-13 has been linked to various cancers and neurodegenerative diseases. Changes in its expression or function can lead to aberrant apoptosis contributing to tumor growth and resistance to chemotherapy. In neurodegenerative disorders such as Alzheimer's disease Bcl2-L-13 influences neuronal apoptosis pathways often in association with other proteins like APP or presenilin. Understanding the role of Bcl2-L-13 in these conditions helps develop targeted therapies aimed at modulating its activity to restore normal apoptotic processes.