Abcam, ab204234, Anti-Tuftelin 1 antibody

Size: 100µL
Rabbit Polyclonal Tuftelin 1 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TUFT1 aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TUFT1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q9NNX1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tuftelin 1 also known as TUFT1 is a protein involved in the mineralization of dental enamel. It holds an approximate molecular mass of 43 kDa and expresses primarily in the ameloblasts the enamel-forming cells of teeth. TUFT1 plays an important mechanical role as a scaffold in the growth and organization of enamel crystals. The protein's expression also appears in other tissues at lower levels though its function outside enamel formation remains less defined.
Biological function summary
Tuftelin 1 contributes to early stages of dental enamel development. It acts as a matrix protein regulating crystal nucleation and growth within the enamel matrix. TUFT1 does not work as an isolated entity but is part of the broader amelogenesis complex interacting with other enamel matrix proteins. It serves a significant biological purpose influencing enamel's hardness and resilience by guiding mineral deposition.
Pathways
TUFT1 interacts closely with enamel-specific pathways and neurodevelopmental processes. In the context of these pathways TUFT1 supports enamel mineralization through interactions with proteins like amelogenin which regulates mineral deposition and enamel maturation. TUFT1 additionally connects with signaling pathways influencing neurodevelopment suggesting a broader range of regulatory activities influencing tissue development.
Tuftelin 1 is implicated in the condition amelogenesis imperfecta a genetic disorder affecting dental enamel development and quality. Mutations in TUFT1 or its associated proteins such as amelogenin lead to enamel defects. Research also suggests links between TUFT1 expression and neurodevelopmental disorders though these associations are still under investigation. Understanding TUFT1's role in these conditions may provide insight into broader implications for developmental biology and genetic pathologies.