Abcam, ab204392, Anti-Codanin-1 antibody

Size: 100µL
Rabbit Polyclonal Codanin-1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CDAN1 aa 1100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CDAN1 aa 1100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8IWY9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Codanin-1 also known as Codanto is a protein encoded by the CDAN1 gene. It has a molecular mass of approximately 144 kDa. Codanin-1 is generally expressed in the nucleus of cells and is especially present in tissues with high rates of cellular proliferation like bone marrow and fetal liver. This protein plays a role in chromatin assembly and cell cycle regulation.
Biological function summary
Codanin-1 interacts with several cellular processes including DNA replication and repair. It forms part of a larger chromatin remodeling complex. This association highlights its influence on maintaining proper chromatin structure and function which is necessary for accurate gene expression and genomic stability. Codanin-1's involvement in the chromatin assembly process is essential for normal cell function.
Pathways
Codanin-1 interacts with processes related to chromatin remodeling and the DNA damage response. It is part of the chromatin assembly factor pathway which facilitates the integration and organization of new histones into chromatin. Codanin-1 is also potentially linked to the nucleosome assembly pathway. It interacts with proteins like ASF1A and ASF1B which are essential for histone chaperoning and nucleosome assembly during DNA replication.
Codanin-1 has a strong association with congenital dyserythropoietic anemia type I (CDA I) a rare form of anemia. This condition arises from mutations in the CDAN1 gene causing ineffective erythropoiesis. The Codanin-1 protein links with the hemoglobin subunit proteins during erythroid cell development and plays a critical role in red blood cell maturation. This connection highlights the importance of Codanin-1 in maintaining normal blood cell production and function.