Abcam, ab204400, Anti-SERINC5 antibody

Size: 100µL
Rabbit Polyclonal SERINC5 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SERINC5 aa 300-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SERINC5 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.Q86VE9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein SERINC5 also known as Serine Incorporator 5 or TDE1 is involved in the incorporation of serine into membrane lipids. Its molecular mass is approximately 51 kDa. SERINC5 localizes to the membrane and is primarily expressed in the brain and testes although it can be found in other tissues as well. The protein functions as a transmembrane protein interacting with other cellular components to perform its role in lipid metabolism.
Biological function summary
SERINC5 modifies the lipid composition of cellular membranes. This activity influences various cellular processes including membrane trafficking and signaling. SERINC5 does not act as a part of a larger protein complex but interacts with other proteins associated with the cellular membrane to exert its function. Through its activity SERINC5 plays a role in ensuring the proper distribution and proportion of serine-derived lipids.
Pathways
SERINC5 contributes to lipid biosynthesis and membrane biology processes. It participates in lipid metabolic pathways where its function intersects with pathways involving serine metabolism. SERINC5 is related to proteins like serine palmitoyltransferase which initiates the synthesis of sphingolipids a significant class of membrane lipids. This interaction highlights SERINC5's role in lipid homeostasis.
Changes in SERINC5 have implications for viral infections and neurological conditions. The protein influences the replication cycle of certain viruses including HIV-1 by altering membrane composition and potentially affecting viral entry or assembly. SERINC5's role in membrane integrity also connects it to neurological disorders where its interaction with proteins involved in neurotransmission might lead to altered neural functions. Understanding SERINC5’s involvement could offer insights for therapeutic strategies for these diseases.