Abcam, ab204403, Anti-MBD6 antibody

Size: 100µL
Rabbit Polyclonal MBD6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MBD6 aa 600-750.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MBD6 aa 600-750. The exact immunogen used to generate this antibody is proprietary information.Q96DN6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MBD6 also known as methyl-CpG-binding domain protein 6 acts by binding to methylated DNA but the exact mechanistic role in transcription regulation remains not fully defined. It has an approximate molecular weight of 131 kDa. Researchers have observed MBD6 expression mainly in the nucleus of cells where it likely interacts with other nuclear proteins. It may play a role in chromatin organization due to its DNA-binding properties.
Biological function summary
MBD6 influences gene expression through its association with chromatin modification processes. It often functions as part of a protein complex involved in reading DNA methylation marks which affects transcriptional regulation. This complex includes proteins engaged in methylation-dependent mechanisms to modify chromatin structure and modulate gene expression.
Pathways
The role of MBD6 integrates within DNA methylation and chromatin remodeling pathways. These pathways are essential for regulating cell differentiation and development. MBD6 interacts with proteins such as MeCP2 and MBD2 which also participate in chromatin remodeling and transcriptional repression by reading methylation signals and executing change in gene expression profiles.
Scientists have linked MBD6 to neurological disorders and certain cancer types. It shares pathways with MeCP2 which associates with Rett syndrome implicating potential roles of MBD6 in neural development and function. Additionally MBD6's involvement in chromatin modulation connects it to the dysregulation observed in some cancers suggesting its influence on cancer progression may be due to altered methylation and gene expression profiles.