Abcam, ab204490, Anti-NUP188 antibody

Size: 100µL
Rabbit Polyclonal NUP188 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NUP188 aa 250-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NUP188 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.Q5SRE5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The NUP188 protein also known as nucleoporin 188 is a core component of the nuclear pore complex (NPC). It has a molecular mass of approximately 188 kDa. This protein is expressed in various tissues where it contributes to the structure and function of the NPC which is essential for the transport of molecules between the nucleus and cytoplasm. NUP188 interacts directly with other nucleoporins to form the intricate architecture of the NPC facilitating the regulation of nucleocytoplasmic exchange.
Biological function summary
NUP188 plays a critical role in maintaining the integrity of the nuclear envelope. It is an integral part of the nuclear pore complex joining together with other proteins to ensure the selective transport of macromolecules. NUP188 contributes to the regulation of gene expression and cell cycle progression by mediating nucleoplasmic communication. Its presence in the NPC structure ensures that the necessary components for DNA replication and repair can pass through the nuclear envelope.
Pathways
NUP188 is involved in important cellular transport pathways such as the nucleo-cytoplasmic transport pathway. This pathway includes other nucleoporins like NUP93 and NUP205 which work with NUP188 to facilitate the movement of proteins and RNA. The precise regulation of these pathways supports functions like RNA processing and ribosomal biogenesis ensuring proper cellular operation and survival.
Disruptions in NUP188 function have associations with cancer and neurodegenerative diseases. Altered expression or mutation of NUP188 can lead to changes in the nucleocytoplasmic transport mechanism potentially contributing to tumorigenesis or the progression of neurological conditions. Its interaction with other nucleoporins like NUP93 in these contexts highlights the potential for broad effects on cellular homeostasis making it significant in the study of related pathologies.