Abcam, ab204555, Anti-SMIM12 antibody

Size: 100µL
Rabbit Polyclonal SMIM12 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SMIM12 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SMIM12 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96EX1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SMIM12 also known as Small Integral Membrane Protein 12 is a protein with a mass of approximately 13 kDa. This protein integrates into cellular membranes suggesting it plays a role in membrane-related processes. SMIM12 exhibits expression in many tissues with notable expression in the testes and liver. Its localization in these areas indicates its involvement in specific physiological processes relevant to these organs.
Biological function summary
SMIM12 contributes to cellular mechanisms by participating in signaling functions related to membrane integrity and transport. It appears to be part of a larger protein complex indicating it interacts with other membrane proteins to coordinate cellular activities. Such interactions might suggest it facilitates communication between intra- and extracellular environments important for maintaining normal cell functionality.
Pathways
Understood functions of SMIM12 place it within the cellular signaling pathways linked to membrane integrity and protein transport. It interacts closely with proteins such as CD47 and integrins which are important for cell adhesion and immune response signaling. These pathways ensure cellular communication and proper response to physiological changes.
SMIM12 shows relevance to conditions like testicular dysfunction and liver disease. Its interaction with proteins like integrins suggests a role in disorders affecting membrane stability and cellular adhesion. Understanding these interactions could provide insights into pathological conditions resulting from disrupted membrane functions and aid in the development of new therapeutic strategies.