Abcam, ab204583, Anti-Keratinocyte differentiation associated protein antibody

Size: 100µL
Rabbit Polyclonal Keratinocyte differentiation associated protein antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KRTDAP aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KRTDAP aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P60985

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Keratinocyte differentiation associated protein also known as KDAP is a protein integral to the process of skin cell differentiation. This protein has a mass of around 25 kDa and is expressed predominantly in the epidermis where keratinocytes reside. KDAP plays a role in the regulation of keratinocyte function and the formation of the outermost layer of skin the stratum corneum. The presence of KDAP has been observed across various layers of the epidermis suggesting its involvement in the progressive stages of keratinocyte maturation.
Biological function summary
This protein enhances the differentiation process of keratinocytes important for maintaining skin barrier function and homeostasis. KDAP does not operate as part of a larger complex but independently regulates specific signaling pathways pivotal for keratinocyte histology. It participates in cellular activities that drive keratinocyte image formation ensuring orderly stratification and keratin composition. These functions are critical for developing functional and resilient skin.
Pathways
KDAP is a significant player in pathways associated with skin development and repair. One essential pathway includes the Notch signaling pathway which involves linked proteins like Notch receptors that influence cell fate determination and differentiation. Another pathway is the epidermal growth factor receptor (EGFR) pathway where KDAP's activity connects to related proteins like EGFR that regulate cell proliferation and survival. These pathways highlight KDAP's role in maintaining the balance between proliferation and differentiation integral to healthy skin formation and response to damage.
KDAP shows associations with skin-related conditions such as psoriasis and atopic dermatitis. Psoriasis involves abnormal keratinocyte proliferation which could be linked to KDAP's regulatory functions. The protein's dysregulation could also affect atopic dermatitis a disorder associated with skin barrier dysfunction. In these cases proteins such as filaggrin a vital component of the skin barrier interact within the same framework suggesting that KDAP may influence or reflect changes in these conditions.