Abcam, ab205021, Anti-UNK unkempt antibody

Size: 100µg
Rabbit Polyclonal UNK unkempt antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human UNK aa 750 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human UNK aa 750 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9C0B0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UNK also known as unkempt is a protein characterized by its mass of about 105 kDa. It performs as a transcription factor influencing gene expression by binding to DNA and regulating transcription processes. This protein shows a significant expression in neuronal tissues indicating its role in neural development and function. Its ability to interact with specific nucleic acid sequences allows it to modulate the activity of target genes critical for cellular processes.
Biological function summary
Transcription factors like UNK are important in various cellular functions impacting cell differentiation and development. UNK contributes to neural development by interacting with other proteins to form complexes that regulate the expression of genes necessary for neural maintenance and differentiation. It plays a role in controlling the expression of genes that are essential for the development and function of the nervous system.
Pathways
Transcription factors such as UNK influence several signaling cascades and in particular UNK is involved in the MAPK signaling pathway. Through this pathway UNK interacts with proteins like ERK which are important in transmitting signals from surface receptors to the DNA in the cell nucleus affecting gene expression. These interactions integrate various external signals adjusting cellular functions like growth and division.
UNK's role has implications in neurodevelopmental disorders including autism spectrum disorder (ASD). Dysfunctional regulation of gene expression linked to UNK can contribute to the pathology of such conditions. Additionally its association with ZNF family proteins highlights its potential involvement in intellectual disabilities. The misregulation of these proteins can disturb normal neuronal function resulting in cognitive deficits.