Abcam, ab206293, Anti-Ionotropic Glutamate receptor 2 + 3 antibody [EPR18115]

Size: 20µL / 100µL / 1mL
Anti-Ionotropic Glutamate receptor 2 + 3 antibody [EPR18115] (ab206293) is a rabbit monoclonal antibody detecting Ionotropic Glutamate receptor 2 + 3 in Western Blot, IP, IHC-P . Suitable for Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 20 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR18115,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-Ionotropic Glutamate receptor 2 + 3 antibody [EPR18115] (ab206293) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P) in Human, Mouse, Rat samples.
What is the molecular weight of Ionotropic Glutamate receptor 2?
Anti-Ionotropic Glutamate receptor 2 + 3 [EPR18115] (ab206293) specifically detects a band for Ionotropic Glutamate receptor 2 (UniProt: P42262) and Ionotropic Glutamate receptor 3 (UniProt: P42263) at a molecular weight of 99kDa.
Trusted by the scientific community
Anti-Ionotropic Glutamate receptor 2 + 3 [EPR18115] (ab206293) was first used in a scientific publication in 2015 and has been cited over 20 times in peer-reviewed journals.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
Discover our selection of trial-size antibodies
Other related products
We have a range of other formats of antibody clone [EPR18115] also available for your convenience: ab206293, Carrier free -
ab251444
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ionotropic glutamate receptor 2 and 3 also known as GluR2 and GluR3 are subunits of AMPA receptors which are ion channels facilitating synaptic transmission. These receptors bind glutamate an important neurotransmitter and become permeable to cations leading to rapid excitatory synaptic signaling. The combined molecular masses of GluR2 and GluR3 subunits are approximately 200 kDa. They are predominantly expressed in the central nervous system particularly in the cortex hippocampus and cerebellum where they contribute to fast synaptic transmission and plasticity.
Biological function summary
These receptors play a role in regulating synaptic strength and neuronal communication. They are part of AMPA receptor complexes vital for modulating synaptic plasticity that underlies learning and memory. GluR2 contains a Q/R site near pore region controlling calcium permeability and channel conductance. This editing is necessary to prevent excessive calcium entry ensuring regulated neuronal activity and maintaining neuroprotective functions.
Pathways
AMPA receptors including GluR2 and GluR3 integrate into the glutamatergic system and are significantly involved in the long-term potentiation (LTP) pathway essential for synaptic plasticity. They interact with proteins like NMDA receptors which help the initiation phase of LTP. They also play a role in excitotoxicity pathways where excessive glutamate can lead to neuronal damage. This interaction with glutamate saves as a bridge between normal synaptic activity and dysregulated excitatory signals.
Ionotropic glutamate receptor dysregulation associates with neurodegenerative diseases like Alzheimer’s disease and seizure disorders such as epilepsy. In Alzheimer's altered receptor trafficking leads to impaired synaptic function with amyloid-beta interacting with receptor systems including NMDA receptors. For epilepsy aberrant glutamate signaling through AMPA receptor subunits like GluR2 and GluR3 is a contributing factor to excitotoxicity and seizure pathogenesis suggesting potential therapeutic targets within receptor signaling pathways.