Abcam, ab208017, Anti-MLLT6 antibody [EPR20977-52]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MLLT6 antibody. Suitable for WB and reacts with Mouse, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR20977-52,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MLLT6 protein also known as AF17 functions mechanically as a transcriptional coactivator. It plays a role in regulating gene expression by interacting with other proteins involved in transcriptional control. The protein has a mass of approximately 122 kDa. Researchers identify its expression in various tissues with a significant presence in hematopoietic tissues. MLLT6 interacts closely with other protein partners to modulate the transcriptional machinery.
Biological function summary
MLLT6 acts as a part of larger protein complexes involved in transcription regulation. It influences the activation and repression of specific gene sets necessary for cell differentiation and development. By integrating into these complexes MLLT6 assists in maintaining the proper function of gene expression programs that control cellular identity and activity. Its contribution is important in processes such as hematopoiesis impacting the development and specialization of blood cells.
Pathways
MLLT6 plays a role in key regulatory networks like the mitochondrial apoptosis and Notch signaling pathways. Through interactions within these pathways MLLT6 associates with proteins like MLLT3 and NOTCH1. These relationships help mediate cell survival proliferation and differentiation signals. This pathway integration allows MLLT6 to influence essential cellular processes aligning transcriptional responses with extracellular signals.
MLLT6 shows a strong connection to certain types of leukemia notably acute myeloid leukemia (AML). Dysregulation of MLLT6 can contribute to leukemogenesis by disrupting normal transcriptional programs and signaling pathways. Additionally studies link MLLT6 to neuroblastoma where its aberrant expression intersects with the MLL protein family impacting tumor development. These disease associations highlight MLLT6's potential value as a therapeutic target and a biomarker for specific hematological and neurological malignancies.