Abcam, ab20922, HRP Anti-HSV1 + HSV2 antibody

Size: 500µL
Rabbit Polyclonal US10 antibody - conjugated to HRP. Suitable for ELISA, ICC and reacts with Herpes simplex virus, Human herpesvirus 2 samples. Cited in 1 publication. Immunogen corresponding to Virus preparation containing Human alphaherpesvirus 1 strain F protein.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Conjugation:HRP,
Carrier free:No,
Reacts with:Herpes simplex virus, Human herpesvirus 2,
Applications:ELISA, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Covalently coupled to a highly purified preparation of Horseradish Peroxidase (RZ>3). Free enzyme is absent. Estimated Molar HRP: IgG substitution is 2-3.

Properties and Storage Information:
Form-Liquid, Purity-IgG fraction, Storage buffer-Preservative: 0.002% Thimerosal (merthiolate)Constituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HSV1 and HSV2 short for Herpes Simplex Virus Type 1 and Type 2 are double-stranded DNA viruses with similar structure and function. They are encapsulated with a lipid envelope featuring glycoproteins which are important for viral entry into host cells. These viruses have a capsid housing the viral genome and weigh around 150 kDa. HSV1 and HSV2 are primarily expressed in epithelial tissues and the nervous system specifically in neurons where they establish latency. HSV1 and HSV2 antibodies as well as anti-HSV1 antibodies and anti-HSV2 antibodies target these viruses aiding in research and diagnostics.
Biological function summary
HSV1 and HSV2 have significant roles in viral infection processes. They form complexes with host cell receptors to facilitate adhesion and entry into cells. Their glycoproteins interact with cellular proteins to trigger fusion and facilitate viral replication. During this process the viruses actively modulate the host's immune response enabling the evasion of immune detection. The ability to remain dormant and reactivate is an important aspect of their biology.
Pathways
HSV1 and HSV2 participate in cell entry and immune evasion processes. These viruses exploit the host's cellular machinery via the MAPK signaling pathway and the PI3K/Akt pathway to enhance viral replication and survival. The viral proteins ICP0 and glycoprotein D are essential for modulating these pathways. These interactions impact the immune response and cellular cycle regulation allowing the virus to maintain its presence within the host.
HSV1 and HSV2 are significant contributors to conditions like oral herpes and genital herpes. They are also associated with severe infections such as Herpes Simplex Encephalitis. The HSV1 and HSV2 target proteins through their interaction with host proteins facilitate these infections. Herpes Simplex Virus type-specific antibodies help in detecting and studying these viruses leading to better understanding and treatment of related conditions.