Abcam, ab20947, Anti-Klebsiella pneumoniae antibody

Size: 500µL
Rabbit Polyclonal Klebsiella pneumoniae antibody. Suitable for ICC/IF and reacts with Klebsiella pneumoniae samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Klebsiella pneumoniae,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Polyvalent for multiple Klebsiella antigens. Product is unabsorbed and may crossreact with related Enterobacteriaceae.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes->95% pure., Storage buffer-Preservative: 0.1% Sodium azide Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Klebsiella pneumoniae sometimes referred to as Kleb pneumo is a gram-negative bacterium known for its role in human infections. It has a molecular mass of around 5.5 million Daltons. Klebsiella pneumoniae is typically found in the intestinal tract of humans and animals. Beyond the intestines it can colonize the respiratory tract and other mucosal surfaces making it a common pathogen in hospital settings. In laboratory cultures Klebsiella pneumoniae exhibits mucoid colonies due to its polysaccharide capsule which contributes to its virulence.
Biological function summary
Klebsiella pneumoniae plays a significant role in infections. The organism is noted for its pathogenic mechanisms which include evading host immune responses and harboring antibiotic resistance genes. It produces a robust polysaccharide capsule an important virulence factor and a siderophore production system for iron acquisition aiding in infection and persistence in host tissues. The bacterium does not form interlinked complexes with other microorganisms but it interacts with host cells and immune system components influencing the immune response.
Pathways
Klebsiella pneumoniae impacts metabolic routes related to its persistence and virulence. Iron uptake pathways important for its survival and growth involve proteins such as enterobactin which are essential for iron binding and transport. The bacterium also engages in nitrogen metabolism pathways that facilitate its growth in nutrient-limiting environments. Its ability to manipulate these pathways allows it to thrive in diverse environments including host tissues.
Klebsiella pneumoniae is implicated in a variety of infections such as pneumonia and urinary tract infections. The bacterium's capsule a significant virulence factor plays a central role in these infections by preventing phagocytosis. In pneumonia Klebsiella pneumoniae can be particularly severe and is frequently associated with multidrug-resistant strains. Through mechanisms like beta-lactamase production the bacterium ties into the broader issue of antimicrobial resistance complicating treatment options for infections it causes.