Abcam, ab20955, Anti-Hepatitis C Virus NS4 antibody

Size: 250µL
Goat Polyclonal POLG antibody. Suitable for ELISA, WB and reacts with Hepatitis C virus samples. Cited in 1 publication.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Hepatitis C virus,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:Ab20955 recognises Hepatitis C Virus, NS4 Region.

Properties and Storage Information:
Form-Liquid, Purification technique-Ion exchange chromatography, Purification notes-Ab20955 is purified by sodium sulfate precipitation & ion-exchange chromatography. >95% pure., Storage buffer-Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Hepatitis C Virus NS4 also known as nonstructural protein 4 is a component of the Hepatitis C virus important for viral replication and assembly. This protein expressed in infected hepatocytes has an approximate mass of 27 kDa. NS4 plays an integral role in the virus's life cycle impacting processes essential for the formation of viral replication complexes.
Biological function summary
NS4 functions to modulate interactions required for viral polyprotein processing and pathogenicity. It forms a part of the larger nonstructural protein complex interacting with other viral proteins such as NS3 and NS5A. These interactions significantly contribute to membrane rearrangement and the stabilization of the replication complex. The interplay of NS4 with various host cell factors aids in creating a favorable environment for viral replication.
Pathways
NS4 is deeply involved in the viral replication pathway and host immune response modulation. In the viral replication pathway NS4 acts in concert with NS3 which is a serine protease. Additionally it manipulates the host immune mechanisms to evade detection impacting interferon signaling pathways. Through these pathways NS4 supports the continuity of viral propagation within host cells.
NS4 correlates predominantly with Hepatitis C infection which can progress to chronic Hepatitis C and lead to liver cirrhosis or hepatocellular carcinoma. The interaction of NS4 with other viral proteins like NS5A further exacerbates the pathogenic effects of the virus promoting disease progression. Understanding NS4's role aids in the development of effective antiviral therapies targeting these interactions.