Abcam, ab212044, Anti-HSPA6 antibody

Size: 50µL
Rabbit Polyclonal HSPA6 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HSPA6 aa 350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HSPA6 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P17066

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 89% Tris glycine, 10% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HSPA6 protein also known as Heat Shock 70kDa Protein 6 plays an important role in cellular stress response. It has a molecular weight of approximately 70 kDa. HSPA6 belongs to the heat shock protein 70 family which helps cells cope with stress by functioning as molecular chaperones. This protein is expressed in various tissues but is notably upregulated in response to heat shock and other stress conditions. HSPA6 assists in maintaining protein homeostasis by preventing the aggregation of unfolded proteins and assisting in the refolding process.
Biological function summary
Heat Shock 70kDa Protein 6 acts as a molecular chaperone and facilitates the stabilization and proper folding of unfolded or misfolded proteins under stress conditions. It operates independently and does not appear to form part of a larger protein complex unlike some other heat shock proteins. HSPA6 helps cells recover from stress damage by transporting proteins across cellular membranes and aiding in the assembly of multiprotein complexes. This function is important for maintaining cellular integrity especially during and after exposure to stressors.
Pathways
Heat Shock 70kDa Protein 6 plays a role in the cellular stress response pathway. It synergistically collaborates with other heat shock proteins like HSP70 and HSP90 which are important in protein folding and protection against stress-induced damage. Additionally HSPA6 interacts within the unfolded protein response pathway a critical mechanism in the endoplasmic reticulum to manage stress. This relationship with other heat shock proteins and pathways allows cells to maintain function and resilience under stress.
Heat Shock 70kDa Protein 6 has links to conditions associated with cellular stress including neurodegenerative diseases such as Alzheimer’s disease. Misfolded proteins are a hallmark of such diseases and HSPA6’s chaperoning functions are relevant to these pathological processes. Additionally HSPA6 has been studied in the context of cancer where its expression can be altered due to the high metabolic and replication stress experienced by tumors. In these disorders HSPA6 works alongside HSP70 to combat the accumulation of misfolded proteins and preserve cellular health.