Abcam, ab212997, Anti-Myeloid Marker antibody [MYADM/971]

Size: 100µg
Mouse Monoclonal Myeloid Marker antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MYADM.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:MYADM/971,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human MYADM.Q96S97

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Myeloid markers are important components involved in the identification and characterization of myeloid cells including monocytes macrophages and granulocytes. These markers such as CD14 CD33 and CD68 have a molecular mass that varies depending on the specific marker. Scientists use these markers to study cell lineage and differentiation in hematopoietic cells. They mainly express in bone marrow spleen and peripheral blood where myeloid cells are abundant. Alternate names for myeloid markers include leukocyte antigens which denote their role in leukocyte classification.
Biological function summary
Myeloid markers play significant roles in immune system function and inflammation processes. They help facilitate cell-cell communication and receptor-mediated phagocytosis in immune responses being part of cooperative complexes on cell surfaces. CD14 for instance often associates with TLR4 to mediate responses to bacterial lipopolysaccharides. By aiding the recognition and removal of pathogens myeloid markers support the body's defenses against infections and inflammation.
Pathways
Myeloid markers actively participate in innate immune signaling and inflammation pathways. They are integral to the toll-like receptor (TLR) pathway which helps recognize pathogen-associated patterns. For instance CD14 is involved in the TLR pathway that activates NF-kB and MAP kinase leading to inflammatory cytokine production. Myeloid markers also connect with complement pathways interacting with immune proteins like C3 which further signal cellular immune responses to pathogens.
Altered myeloid marker expression associates with conditions such as leukemia and chronic inflammatory diseases. Acute myeloid leukemia (AML) often involves abnormal expression of myeloid markers like CD33 impacting the differentiation of myeloid-lineage cells. Additionally in chronic inflammatory diseases such as rheumatoid arthritis changes in myeloid marker activity link to dysregulated immune responses. Through these conditions proteins like CD33 become important for diagnostic and therapeutic target considerations.