Abcam, ab214316, Anti-Desmuslin/SYN antibody

Size: 100µL
Rabbit Polyclonal Desmuslin/SYN antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SYNM aa 500-550 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SYNM aa 500-550 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.O15061

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Desmuslin also known as SYN or Synemin is an intermediate filament protein with a mass of approximately 180 kDa. It is prominently expressed in muscle tissues including skeletal cardiac and smooth muscles. Desmuslin integrates into the cytoskeleton providing essential structural support and maintaining cellular integrity. Its expression is not restricted to muscle tissues; desmuslin also appears in certain non-muscle cells indicating its diverse functional roles.
Biological function summary
The protein desmuslin plays an important role in maintaining cellular architecture and mechanical stability. It associates closely with the cytoskeletal network and participates in the actin-binding protein complex. Desmuslin interacts with various cytoskeletal components anchoring them to the sarcolemma and linking the extracellular matrix to the cytoskeleton. This interaction supports cellular resilience against mechanical stress and contributes to tissue homeostasis.
Pathways
The protein desmuslin integrates into cell adhesion and signaling pathways. It links mechanically to pathways involving integrins which facilitate cell adhesion and communication with the extracellular matrix. Through these pathways desmuslin associates with proteins like plectin and dystrophin which also contribute to structural integrity. This interaction aids in the transmission of mechanical signals integrating external stimuli with intracellular responses and supports proper muscle function.
The protein desmuslin associates with conditions such as muscular dystrophy and cardiomyopathies. Mutations or dysregulation of desmuslin can disrupt muscle integrity leading to progressive muscle weakness and degeneration. Desmuslin interacts with the dystrophin-glycoprotein complex which when altered can also contribute to the development of muscular dystrophy. Additionally desmuslin plays a role in maintaining cardiac muscle function and its dysfunction relates to certain cardiomyopathies posing significant implications for cardiac health.