Abcam, ab214488, Anti-TROP2 antibody [EPR20043]

Size: 100µL / 1mL
Anti-TROP2 antibody [EPR20043] (ab214488) is a rabbit monoclonal antibody detecting TROP2 in Western Blot, Flow Cytometry (Intra), Flow Cytometry, IHC-P, ICC/IF . Suitable for Human, Mouse, Rat . - Clone EPR20043 is the most cited clone to TROP2 - KO validated for confirmed specificity - Biophysical QC for unrivalled batch-batch consistency - Over 10 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR20043,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Mouse, Human,
Applications:IHC-P, Flow Cyt (Intra), ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Anti-TROP2 antibody [EPR20043] (ab214488) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P and WB.
Abcam's high quality manufacturing and validation processes ensure Anti-TROP2 antibody [EPR20043] (ab214488) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
The specificity of Anti-TROP2 antibody [EPR20043] (ab214488) has been confirmed by Western Blot testing in TROP2 knockout MCF7 cells.
Anti-TROP2 antibody [EPR20043] (ab214488) has 9 independent reviews from customers.
Anti-TROP2 antibody [EPR20043] (ab214488) specifically detects TROP2 (UniProt ID: P09758; Molecular weight: 34kDa) and is sold in 100 µL and 1 mL selling sizes.
Conjugation-ready, carrier free format available for antibody clone EPR20043 -
ab222935
Antibody clone EPR20043 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor
647, Alexa Fluor
488, PE, APC, HRP, Alkaline Phosphatase, Alexa Fluor
594, Alexa Fluor
568, Alexa Fluor
ab281582
ab281933
ab303028
ab303029
ab303030
ab308661
ab310365
ab312357
ab321379
TROP2 is a cell surface protein that is overexpressed in various cancers, playing a crucial role in tumor growth and metastasis. In immuno-oncology, TROP2 is a target for antibody-drug conjugates and is associated with resistance to certain immunotherapies.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TROP2 also known as TACSTD2 or tumor-associated calcium signal transducer 2 is a single-pass type I membrane glycoprotein. This protein is about 35 kDa in mass and primarily expresses in epithelial tissues. It acts as a transmembrane receptor that plays a role in signal transduction due to its domain structure binding and activation processes on the cell surface. TROP2 exhibits high expression in several types of tumors making it a potential target for therapeutic antibodies like anti-TROP2 anti trop2 or anti-TROP-2.
Biological function summary
TROP2 mediates calcium signaling and cell proliferation. It functions by being a part of a signaling complex on the cell membrane which affects multiple cellular activities such as cell growth motility and survival. Its role in maintaining the integrity of the epithelial cell layer also shows TROP2's significance in normal tissue homeostasis. The interaction of TROP2 with the extracellular matrix and other cell surface proteins support the structural integrity and communication between cells.
Pathways
TROP2 plays a central role in the PI3K/AKT and MAPK signaling pathways that regulate cell growth and survival. Within these pathways TROP2 works in concert with proteins like ERK and AKT important for transmitting extracellular signals into appropriate cellular responses. These pathways are key regulators of many physiological processes including cell cycle progression and apoptosis prevention.
TROP2 is strongly associated with several types of cancers particularly epithelial cancers like breast and pancreatic cancer. Overexpression of TROP2 in tumors often correlates with poor prognosis and aggressive disease phenotypes. Interaction between TROP2 and proteins like EGFR in cancer cell signaling pathways amplifies tumor progression and metastasis. Understanding these associations makes TROP2 a significant target in developing therapeutic strategies for cancer treatment.