Abcam, ab214816, Anti-IP6K1 (phospho S118 + S121) antibody [EPR19852]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal IP6K1 phospho S118 + S121 antibody. Suitable for IP, Dot, WB and reacts with Human, Synthetic peptide, Transfected cell line - Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19852,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WB, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein inositol hexakisphosphate kinase 1 (IP6K1) also known as IHPK1 plays an important mechanical role in cellular signaling. It catalyzes the conversion of inositol hexakisphosphate (IP6) to diphosphoinositol pentakisphosphate (IP7). IP6K1 has a molecular mass of approximately 48 kDa. It is expressed in various tissues including the brain testis and pancreas where it is involved in multiple cellular processes.
Biological function summary
IP6K1 influences several critical cell functions such as energy metabolism cell migration and apoptosis. It also participates in the regulation of insulin secretion. IP6K1 does not primarily form part of a complex; however it interacts with proteins that impact these biological functions. Its role in metabolism and signaling pathways marks it as a significant contributor to maintaining cellular homeostasis.
Pathways
IP6K1 plays a part in the inositol phosphate metabolism and insulin signaling pathways. Within these pathways IP6K1 interacts closely with proteins such as Akt mTOR and other kinases modulating their activities. These interactions affect cellular energy status and influence growth factor signaling pathways impacting numerous downstream biological processes.
IP6K1's activity links it to conditions such as type 2 diabetes and obesity. In type 2 diabetes IP6K1 interacts with insulin-signaling proteins affecting glucose homeostasis and insulin sensitivity. The protein's role in obesity relates to its influence on energy metabolism as it can impact energy expenditure and fat storage with potential interactions involving with proteins like leptin and AMPK.