Abcam, ab216126, Anti-WDR63 antibody

Size: 100µL
Rabbit Polyclonal WDR63 antibody. Suitable for IHC-P, WB and reacts with Human, Transfected cell lysate - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DNAI3 aa 400-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DNAI3 aa 400-550. The exact immunogen used to generate this antibody is proprietary information.Q8IWG1

Product details:
The antibody solution should be gently mixed before use.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDR63 also known as WD Repeat Domain 63 is a protein that plays a significant mechanical role in cellular processes. It is a protein which weighs approximately 97 kDa. This protein belongs to the WD repeat protein family characterized by repetitive sequences that aid in protein-protein interactions. WDR63 is expressed across various tissues with notable expression in the testis suggesting a role in reproductive biology.
Biological function summary
WDR63 participates in processes critical to cell structure and function. It associates with cellular structures that facilitate cell division. WDR63 is part of macromolecular complexes necessary for constructing cilium the antenna-like structures on the cell surface. Its involvement in such complexes aids in maintaining ciliary structure and function contributing to cellular signaling and movement.
Pathways
WDR63 has roles in pathways linked to ciliary function and cell cycle regulation. It is involved in the Hedgehog signaling pathway which is important for embryonic development and tissue homeostasis. This pathway interacts with proteins like SMO (Smoothened) and PTCH (Patched) regulating cellular responses to extracellular signals. Additionally WDR63 contributes to the centrosome cycle coordinating centrosome maturation and separation during cell division.
Research indicates links between WDR63 and specific ciliopathies. Mutations or dysregulation of WDR63 may contribute to conditions like Bardet-Biedl syndrome a disorder associated with impaired cilia function leading to issues in vision weight and renal function. WDR63 may interact with BBS1 and BBS10 proteins both relevant to the disorder. Understanding WDR63's role may offer insights into therapeutic strategies for ciliary-related diseases.