Abcam, ab216312, Dovitinib, class III-V receptor tyrosine kinase inhibitor

Size: 5mg / 25mg
MW 392.4 Da, Purity >99%. Potent, selective inhibitor of class III-V receptor tyrosine kinases (RTKs). Inhibits FLT3 (IC 50 = 1 nM), c-KIT (IC 50 = 2 nM), FGFR (IC 50 = 8 nM), VEGFR1/2/3 (IC 50 values are 10 nM, 13 nM and 8 nM respectively), PDGFRβ (IC 50 = 27 nM), and CSF-1R (IC 50 = 36 nM). Selectively blocks growth of B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.
Key facts
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:392.4 Da,
Molecular formula:C21H21FN6O,
PubChem:9886808,
Nature:Synthetic,
Solubility:Soluble in DMSO (up to 30 mg/ml),
Biochemical name:CID 9886808,
Biological description:Potent, selective inhibitor of class III-V receptor tyrosine kinases (RTKs). Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 values are 10 nM, 13 nM and 8 nM respectively), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM). Selectively blocks growth of B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.,
Canonical smiles:CN1CCN(CC1)C2=CC3=C(C=C2)NC(=C4C(=C5C(=NC4=O)C=CC=C5F)N)N3,
Isomeric smiles:CN1CCN(CC1)C2=CC3=C(C=C2)N/C(=C/4\C(=C5C(=NC4=O)C=CC=C5F)N)/N3,
InChi:InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11,24-25H,7-10,23H2,1H3/b20-18-,
InChiKey:KCOYQXZDFIIGCY-ZZEZOPTASA-N,
IUPAC Name:(3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions