Abcam, ab216485, Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody

Size: 100µL
Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody (ab216485) is a rabbit polyclonal antibody detecting Nicotinic Acetylcholine Receptor alpha 7 in Western Blot, IHC-P, ICC/IF . Suitable for Human, Mouse, Rat . - Over 20 publications
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human, Rat,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CHRNA7 aa 450 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P36544

Product details:
Product Specifications
Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody (ab216485) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-P, WB in human, mouse, rat samples.
Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody (ab216485) specifically detects Nicotinic Acetylcholine Receptor alpha 7 (UniProt ID: P36544; Molecular weight: 54kDa) and is sold in 100 µL selling sizes.
Quality and Validation
Abcam's high quality validation processes ensure Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody (ab216485) has high sensitivity and specificity.
Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody (ab216485) has been cited over 20 times in peer reviewed journals and is trusted by the scientific community.
Anti-Nicotinic Acetylcholine Receptor alpha 7 antibody (ab216485) has 5 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Proclin 300Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Nicotinic Acetylcholine Receptor alpha 7 (nAChR α7) is an important ligand-gated ion channel involved in neurotransmission. It is commonly known by its alternate name α7-nAChR. This receptor plays a critical role in fast synaptic transmission and is activated by the neurotransmitter acetylcholine. The nAChR α7 is a homomeric receptor meaning it is composed entirely of alpha 7 subunits each with a molecular mass of approximately 57 kDa. It is expressed predominantly in the central nervous system especially in the brain but also found in other tissues like the immune system.
Biological function summary
The nAChR α7 facilitates the influx of cations like calcium and sodium upon activation influencing cellular signaling events. As part of the larger family of nicotinic acetylcholine receptors it functions within a pentameric complex structure. The receptor is essential for cognitive processes including attention and memory by modulating neurotransmitter release and plasticity. It also interacts with other neurotransmitter pathways and may play a role in anti-inflammatory processes due to its expression in non-neuronal tissues.
Pathways
The nAChR α7 is involved in the cholinergic signaling pathway and the broader calcium signaling pathway. It contributes to the regulation of intracellular calcium levels which are important for various cellular functions. The receptor works alongside other proteins such as bungarotoxin-sensitive nAChRs and muscarinic acetylcholine receptors (mAChRs) to mediate complex neurotransmitter systems. The interplay between these receptors highlights the receptor's importance in maintaining synaptic function and plasticity.
Research indicates a connection between nAChR α7 and neurodegenerative diseases like Alzheimer’s disease and schizophrenia. The receptor's dysfunction or altered expression has been linked to cognitive deficits associated with these conditions. In Alzheimer's disease the interaction of nAChR α7 with amyloid-beta peptides may contribute to neurotoxicity. Additionally the receptor's association with cytokine release in immune cells suggests a potential role in inflammatory disorders. Its linkage with other neurotransmitter systems such as the involvement of nAChR agonists further demonstrates the receptor's relevance to these neurological and immune-associated diseases.