Abcam, ab216869, Anti-DPS1 antibody [EPR20843]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal DPS1 antibody. Suitable for IP, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR20843,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:collaborative project

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DPS1 also known as Damage Protection Protein 1 plays a significant role at the mechanical level by acting as a DNA-binding protein that protects DNA from oxidative damage. The protein has an approximate mass of 20 kDa and it is mainly expressed in stress-responsive tissues including the liver and kidney. DPS1 stabilizes DNA by forming homodimers that bind to the DNA providing a shield against harmful agents like free radicals.
Biological function summary
DPS1 contributes to the cellular response to oxidative stress and is integral in the defense mechanism of cells. It interacts with various antioxidants to minimize cellular damage and is a component of the multiprotein DNA protection complex. This complex ensures that cells maintain genomic integrity under stressful conditions enhancing the survival rate of cells exposed to damaging agents.
Pathways
DPS1 is closely involved in the oxidative stress response pathway and the DNA repair pathway. These pathways are critical for cellular homeostasis and cellular longevity. DPS1 works closely with proteins such as NRF2 and SOD1 to modulate the response to oxidative stress coordinating the reduction of reactive oxygen species and initiation of DNA repair processes.
DPS1 has associations with conditions like cancer and neurodegenerative disorders. In cancer disruptions in DPS1 activity can lead to increased DNA damage accumulation contributing to tumor progression. In neurodegenerative disorders the protein's impaired function can result in heightened oxidative stress and neuronal damage. DPS1 interacts with proteins such as p53 in cancer influencing cellular responses to DNA damage and with proteins like APP in neurodegenerative diseases affecting pathways that mitigate oxidative stress.