Abcam, ab216953, Anti-GRINA antibody

Size: 100µL
Rabbit Polyclonal GRINA antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GRINA also known as Glutamate Receptor Ionotropic NMDA Associated Protein 5 or NMDAR Subunit 5 is a protein encoded by the GRINA gene. It is a transmembrane protein involved in the regulation of ion channels specifically interacting with the NMDA receptor complexes. GRINA weighs approximately 50 kDa and is expressed predominantly in the central nervous system notably in the cerebral cortex and hippocampus. Its presence in these regions indicates its role in neuronal communication and signaling.
Biological function summary
The GRINA protein modulates calcium ion flux in neurons influencing neuronal excitability and synaptic plasticity. This role makes it an important component in maintaining normal neurotransmission. GRINA associates with NMDA receptor complexes which consist of several other subunits. This association governs the receptor's function in synaptic signaling and plasticity affecting learning and memory processes.
Pathways
GRINA participates in the glutamatergic synapse and calcium signaling pathways. In these pathways GRINA works alongside the protein GRIN1 a critical subunit of the NMDA receptor complex to facilitate ion flow and synaptic transmission. This involvement situates GRINA as an important regulatory factor in neuronal activity and signal propagation within the brain.
GRINA has links to neurodegenerative diseases and psychiatric disorders including Alzheimer’s disease and schizophrenia. Its association with the NMDA receptor complex implies its contribution to the pathophysiology of these conditions. For example alterations in GRINA function can affect GRIN2B another NMDA receptor subunit implicated in neuropsychiatric diseases further connecting GRINA to these disorders. Understanding GRINA's interactions and functions can offer insights into therapeutic targets for these diseases.