Abcam, ab218011, Anti-Myelin Basic Protein antibody [EPR21188] - Oligodendrocyte Marker

Size: 20µL / 100µL / 1mL
Anti-Myelin Basic Protein antibody [EPR21188] (ab218011) is a rabbit monoclonal antibody detecting Myelin Basic Protein in Western Blot, IHC-P, IHC-Fr . Suitable for Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 20 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR21188,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-Fr, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Anti-Myelin Basic Protein antibody [EPR21188] (ab218011) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-Fr, IHC-P, WB in human, mouse, rat samples.
Anti-Myelin Basic Protein antibody [EPR21188] (ab218011) has been cited over 28 times in peer reviewed journals and is trusted by the scientific community.
Abcams high quality manufacturing and validation processes ensure Anti-Myelin Basic Protein antibody [EPR21188] (ab218011) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Anti-Myelin Basic Protein antibody [EPR21188] (ab218011) has 4 independent reviews from customers.
Anti-Myelin Basic Protein antibody [EPR21188] (ab218011) specifically detects Myelin Basic Protein (UniProt ID: P04370; Molecular weight: 27kDa) and is sold in 100 uL and 1 mL selling sizes.
Conjugation-ready, carrier free format available for antibody clone EPR21188 -
ab23378
Antibody clone EPR21188 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 594, Alexa Fluor® 568, Alexa Fluor® 488, Alexa Fluor® 555 (ab31179,
ab31371
ab314162
ab315358
Myelin Basic Protein (MBP) is a key component of the myelin sheath and is extensively studied in neuroscience. It is crucial for maintaining myelin integrity and ensuring effective nerve signal transmission. Changes in MBP expression can signal myelin damage, which is significant in various neurodegenerative conditions, such as multiple sclerosis (MS) and Alzheimer's disease (AD). Research on MBP helps in understanding myelin-related pathology and neuronal dysfunction, highlighting its importance in the broader study of neurodegenerative diseases.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The myelin basic protein also referred to as MBP or MBP protein plays an important mechanical role in the central nervous system. It is a major component in the formation and stability of the myelin sheath which wraps around nerve fibers to ensure efficient neural signaling. The molecular weight of MBP can vary due to alternative splicing; one common form has a mass of about 18.5 kDa. MBP is expressed predominantly in oligodendrocytes within the brain and spinal cord where it helps form the myelin sheath. MBP2 is another variant that may be mentioned in some contexts.
Biological function summary
MBP is not just a passive structural element; it binds and interacts with lipids and other proteins to maintain the compact structure of the myelin sheath. MBP forms part of a complex that includes various other proteins and lipids ensuring the stability and function of myelin. Misfolding or altered expression of MBP can compromise myelin integrity affecting the insulation of neural pathways and signal transmission.
Pathways
MBP is an essential component in the pathways of myelination and neural plasticity. It plays a role in the signaling pathways that stimulate the development and maintenance of the myelin sheath. The protein interacts with other elements of the myelin sheath such as proteolipid protein (PLP) and myelin-associated glycoprotein (MAG) to coordinate its formation and repair processes.
MBP is linked closely to multiple sclerosis (MS) and other demyelinating conditions. Damage to or autoimmunity against MBP leads to the degradation of the myelin sheath contributing to the neurological symptoms in MS. The protein interacts with elements of the immune system with autoantibodies targeting MBP often found in MS patients. Another disorder associated with MBP dysfunction is Charcot-Marie-Tooth disease where abnormal MBP expression and structure can impact nerve function.