Abcam, ab220288, Anti-CTF18 antibody

Size: 100µL
Rabbit Polyclonal CTF18 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CHTF18 aa 850 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CHTF18 aa 850 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8WVB6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CTF18 also known as Chromosome Transmission Fidelity 18 Homolog is a protein involved in DNA replication and repair. It has a molecular weight of approximately 112 kDa. CTF18 can be found in the nucleus of the cell where it interacts with other factors essential for maintaining genome integrity. Researchers identify CTF18 as a subunit of the Ctf18-RFC (Replication Factor C) complex which is key in the loading of PCNA (Proliferating Cell Nuclear Antigen) onto DNA during replication.
Biological function summary
CTF18 plays a significant role in chromosome cohesion during cell division. It forms part of the Ctf18-RFC complex which assists in the establishment of sister chromatid cohesion. This protein complex is important for the proper segregation of chromosomes during mitosis preventing genomic instability. The coordination and function of CTF18 with other cohesin complex proteins ensure the accurate distribution of genetic material into daughter cells.
Pathways
Studies show CTF18 involvement in the DNA damage response and repair pathways. It operates in tandem with proteins like RAD17 and RFC1 participating in DNA damage checkpoint activation and facilitating repair processes. CTF18 links directly to cell cycle control pathways contributing to the maintenance of genomic stability by supporting the DNA replication machinery’s response to damage and stress.
Researchers associate CTF18 with genomic instability-related conditions such as cancer and chromosomal instability syndromes. Alterations or deficiencies in CTF18 expression or function can lead to improper chromosome segregation and an increased risk of tumorigenesis. The connection between CTF18 and proteins like RAD51 which is pivotal for homologous recombination repair highlights the importance of CTF18 in maintaining cellular health.