Abcam, ab220325, Anti-FGF14 antibody

Size: 100µL
Rabbit Polyclonal FGF14 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FGF14 aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FGF14 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q92915

Product details:
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FGF14 known also as fibroblast growth factor 14 is a member of the fibroblast growth factor family. It typically has a mass of approximately 25-30 kDa. Expression of FGF14 is most prominent in the central nervous system particularly in the brain. It is involved in neuronal development and function by interacting with voltage-gated sodium channels affecting nerve cell excitability and signaling.
Biological function summary
The role of FGF14 involves interaction with the intracellular domains of these sodium channels aiding the regulation of channel activity. FGF14 does not function as an independent molecule; rather it forms part of a larger protein complex. Through its action FGF14 affects synaptic plasticity which is the capacity of synapses to strengthen or weaken over time in response to activity levels playing an important role in learning and memory processes.
Pathways
FGF14 is essential in the modulation of ion channel pathways particularly impacting neuronal electrical activity. It participates in pathways regulating nerve cell excitability via association with related proteins like the sodium channel subunits. The Ras/MAPK signaling pathway also shows some interaction further emphasizing its role in neuron differentiation and survival.
FGF14 has connections to neurological conditions such as spinocerebellar ataxia type 27 (SCA27) a disorder characterized by coordination and balance difficulties. Mutations in FGF14 can lead to dysfunctional channel regulation and neuron signaling directly impacting disease manifestation. Researchers have observed connections between FGF14 and other proteins like those involved in the MAPK pathway potentially providing additional insights into therapeutic interventions for related disorders.