Abcam, ab220954, Anti-IFIT5 antibody

Size: 100µL
Rabbit Polyclonal IFIT5 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human IFIT5 aa 300-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human IFIT5 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.Q13325

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IFIT5 also known as Interferon-induced protein with tetratricopeptide repeats 5 is a protein with a molecular mass of approximately 56 kDa. This protein is expressed mainly in the cytoplasm where it functions by specifically binding to single-stranded RNAs lacking 2'-O-methylation at their 5'-cap structure. This recognition allows IFIT5 to distinguish self from non-self RNA an important element in immune defense mechanisms. Its ability to sense and bind to viral RNA makes it an important player in the host's innate immune response.
Biological function summary
IFIT5 is involved in antiviral defense and immune response regulation. It does not function as part of a multi-protein complex but interacts with various signaling molecules to amplify immune responses. By selectively binding to foreign RNA IFIT5 can inhibit viral replication and modulate type I interferon signaling pathways. It plays a significant role in restricting viral protein synthesis giving the host organism time to mount an adaptive immune response.
Pathways
IFIT5 is closely associated with the interferon signaling pathway and the innate immune response pathway. Through its interactions it affects the Jak-STAT signaling pathway which is important for the induction of antiviral states in cells. IFIT5 also has functional links with other proteins such as RIG-I an important sensor in the detection of viral RNAs. Together they provide a robust early immune defense by facilitating cytokine production and ensuring rapid response to infections.
IFIT5 has been linked to viral infections and certain inflammatory conditions. Its role in antiviral defense connects it to diseases such as hepatitis C where the protein's influence on interferon action can affect viral persistence and patient response to treatment. Additionally IFIT5 interaction with proteins like PKR moves it to the context of autoimmune disorders where overactive or dysregulated immune responses can lead to chronic inflammation and tissue damage.