Abcam, ab221098, Anti-RGC-32 antibody

Size: 100µL
Rabbit Polyclonal RGC-32 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RGCC aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RGCC aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9H4X1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RGC-32 also known as response gene to complement 32 is a protein with a molecular weight of approximately 16 kDa. It acts as a cell cycle regulator and transcription coactivator. The protein influences cell division and apoptosis by interacting with other molecules in the cell. RGC-32 is strongly expressed in various tissues including the heart brain liver and kidneys. Its presence in many tissues suggests a widespread role in cellular processes beyond mere response to complement stimuli.
Biological function summary
RGC-32 contributes to cell cycle progression and differentiation. It does not act alone but collaborates with other proteins and enzymes to enable these processes. RGC-32 forms part of a complex that governs key steps in cell cycle regulation influencing cellular proliferation and differentiation pathways. Its involvement in these signaling cascades makes it essential for maintaining proper cell cycle control impacting cellular repair and growth.
Pathways
RGC-32 participates in the regulation of the TGF-β signaling pathway and the Wnt/β-catenin pathway. These two pathways are important for cellular growth differentiation and immune response. Within the TGF-β signaling pathway RGC-32 enhances the pathway's ability to mediate cell cycle arrest and fibrosis. In connection with the Wnt/β-catenin pathway RGC-32 modulates transcriptional activity that affects cell proliferation. The protein interacts with Smad proteins in TGF-β signaling forming part of the network that responds to growth factors.
RGC-32 is associated with conditions such as cancer and fibrosis. In cancer its overexpression or dysregulation may lead to uncontrolled cell proliferation and tumor development often through interactions with oncogenes and tumor suppressors. In fibrosis RGC-32 contributes to excessive extracellular matrix production playing a part in tissue scarring processes. The protein's interactions with TGF-β signaling are critical in fibrotic disorders while its connection with cyclin-dependent kinases links it potentially to oncogenesis.