Abcam, ab221168, Anti-SMARCD2 antibody

Size: 100µL
Rabbit Polyclonal SMARCD2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SMARCD2 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SMARCD2 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q92925

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SMARCD2 protein also known as BAF60B functions as a subunit of the SWI/SNF chromatin remodeling complex. It possesses a molecular mass of approximately 60 kDa. The protein is widely expressed with notable levels observed in hematopoietic tissues and the central nervous system. SMARCD2 contributes to the modulation of chromatin structure thereby facilitating accessibility of transcriptional machinery to DNA.
Biological function summary
SMARCD2 plays a significant role in the regulation of transcription. As a component of the chromatin remodeling complex it influences gene expression linked to differentiation and development. The SWI/SNF complex which includes SMARCD2 modulates nucleosome positioning on DNA therefore impacting cellular responses to various signaling pathways. The regulatory effects of SMARCD2 within the complex are important for proper lineage commitment and cell fate decisions.
Pathways
SMARCD2 interacts within the context of transcriptional regulation. It is notably involved in the Wnt signaling pathway and the Notch signaling pathway. In these pathways SMARCD2 interacts with proteins like beta-catenin and RBPJ directly influencing the transcription of downstream target genes. SMARCD2's activity within these signaling modules contributes to the regulation of proliferation and differentiation processes.
SMARCD2 is linked to acute myeloid leukemia and neurodevelopmental disorders. Aberrations in the SWI/SNF complex including altered SMARCD2 function can lead to disrupted gene regulation and contribute to leukemogenesis. Similarly mutations affecting SMARCD2 are associated with neurodevelopmental syndromes such as Coffin-Siris syndrome. In these contexts the interplay between SMARCD2 and other complex members such as SMARCA4 influences disease pathogenesis and progression.