Abcam, ab221557, Anti-ARNTL2 antibody

Size: 100µL
Rabbit Polyclonal ARNTL2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BMAL2 aa 450-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human BMAL2 aa 450-550. The exact immunogen used to generate this antibody is proprietary information.Q8WYA1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARNTL2 also known as Brain and Muscle ARNT-Like 2 is a transcription factor with a mass of approximately 75 kDa. It is primarily expressed in various tissues such as liver lung and skeletal muscle. ARNTL2 forms heterodimers with proteins like CLOCK playing an important role in regulating circadian rhythms at the molecular level. The protein facilitates transcription through its basic helix-loop-helix (bHLH) and Per-Arnt-Sim (PAS) domains.
Biological function summary
ARNTL2 functions as a part of a transcriptional regulatory complex that controls the expression of clock-related genes. This complex is pivotal in maintaining homeostasis in biological rhythms. By interacting with other core clock proteins ARNTL2 influences processes like metabolism cell cycle and hormone production. The regulation of these processes helps maintain the body's natural cycles and responds to environmental cues.
Pathways
ARNTL2 is a integral player in the circadian rhythm pathway. This pathway involves interactions with proteins such as CLOCK NPAS2 and PER which synchronize biological functions with day-night cycles. Additionally ARNTL2 links to the gene regulatory network that participates in the metabolism pathway coordinating metabolic responses based on circadian cues and synchronizing body's energy utilization patterns.
ARNTL2 links to conditions like cancer and metabolic syndromes. Its dysregulation can disrupt circadian rhythms thereby affecting cell cycle and metabolic balance. Interactions with proteins like CLOCK and PER2 potentially contribute to these disorders as aberrations in these interactions might lead to tumorigenesis or metabolic imbalances. Understanding ARNTL2's role in these pathways provides insights into therapeutic approaches in related diseases.