Abcam, ab221877, Anti-RNF123 antibody

Size: 100µL
Rabbit Polyclonal RNF123 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RNF123 aa 650-800.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RNF123 aa 650-800. The exact immunogen used to generate this antibody is proprietary information.Q5XPI4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RNF123 also known as KPC1 is an E3 ubiquitin-protein ligase with a molecular mass of approximately 178 kDa. It plays an important role in the ubiquitination process which tags proteins for degradation by the proteasome. RNF123 is widely expressed in human tissues with notable expression in the brain heart and lungs. It functions through its RING finger domain an essential component in the recognition and transfer of ubiquitin molecules to substrate proteins.
Biological function summary
RNF123 modulates cellular function through its ability to control protein turnover. As part of the Skp1-Cullin-F-box (SCF) complex it influences cellular processes such as the cell cycle by regulating proteolytic degradation of proteins. The ligase activity of RNF123 directly contributes to the balance of cellular components impacting cell cycle progression and apoptosis regulation. Its involvement in apoptotic pathways captures attention where it influences cell survival by targeting specific substrates for degradation.
Pathways
RNF123 interacts within the ubiquitin-proteasome pathway and the cell cycle regulation pathways. By fine-tuning the degradation of cyclins and cyclin-dependent kinase inhibitors RNF123 works closely with proteins such as Skp1 and Cullin to ensure proper cell cycle progression. It also impacts pathways related to cell signaling by influencing the turnover of signaling molecules which is important for maintaining cellular homeostasis.
Researchers associate RNF123 with cancer progression and neurodegenerative diseases. Its dysregulation has been linked to the development of certain cancers where it affects the stability of tumor suppressor proteins. Moreover in neurodegenerative disorders such as Alzheimer's RNF123's role in protein homeostasis suggests connections to disease pathogenesis by interacting with proteins like Tau. Understanding RNF123's role in these conditions offers insights into potential therapeutic targets.