Abcam, ab222818, Anti-PTGR1 antibody

Size: 50µL
Rabbit Polyclonal PTGR1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PTGR1 aa 200-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PTGR1 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.Q14914

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes->95%, Storage buffer-pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PTGR1 also known as Prostaglandin Reductase 1 acts as an enzyme within cellular metabolism. It functions by catalyzing the reduction of prostaglandins namely converting 15-keto-prostaglandins to their respective 1314-dihydro metabolites. PTGR1 has a molecular mass of approximately 35 kDa. This enzyme primarily expresses in liver tissues but it is present in other tissues like the lungs and kidneys as well.
Biological function summary
PTGR1 participates in metabolizing prostaglandins which play important roles in inflammation and homeostasis. It does not form part of a larger protein complex but works independently to control the levels of active prostaglandins within cells. This activity regulates physiological processes such as inflammation and vascular tone.
Pathways
Prostaglandin metabolism involves PTGR1's function. It integrates into the arachidonic acid pathway. Within this pathway PTGR1 interacts with other enzymes such as cyclooxygenases and lipoxygenases orchestrating the catabolism of prostaglandins and related lipid compounds. This coordination maintains the balance of inflammatory responses.
PTGR1 contributes significantly to inflammatory conditions and cancer. Elevated or altered PTGR1 activity associates with various inflammatory diseases due to its role in prostaglandin catabolism. Additionally in some cancer types abnormal prostaglandin levels mediated by PTGR1 affect tumor growth. The enzyme's participation in these processes links it to proteins such as COX-2 which is critical for prostaglandin synthesis and inflammation.