Abcam, ab222828, Anti-CERKL antibody

Size: 50µL
Rabbit Polyclonal CERKL antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CERKL.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CERKL.Q49MI3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes->95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein CERKL also called Ceramide Kinase-Like is significant in cellular functions. CERKL has a molecular weight of approximately 70 kDa and expresses mainly in retinal tissue and other neuronal tissues. It is a member of the ceramide kinase family though it lacks measurable kinase activity. CERKL participates in cellular signaling and survival pathways suggesting an important role in maintaining neuronal health.
Biological function summary
CERKL plays a part in cellular protection against oxidative stress and apoptosis. It interacts with other proteins to form complexes that likely enhance cell survival under stressful conditions. Researchers suggest CERKL's function supports photoreceptor cells in the retinan important for light detection in vertebrate vision systems.
Pathways
CERKL contributes to the balance of apoptotic and survival signals within the PI3K/Akt pathway. Its function ensures protection against cellular damage in oxidative environments. CERKL associates with proteins such as Akt a well-known kinase regulating cell survival and growth. Its role in these pathways highlights its impact on cellular resilience.
CERKL mutations link to cases of retinitis pigmentosa and cone-rod dystrophy. These are degenerative retinal diseases leading to vision loss. The connection between CERKL and these disorders indicates its critical role in retinal health. Additionally understanding CERKL's interaction with proteins like RDH12 can offer insights into photoreceptor cell survival and possibly aid in developing therapeutic strategies.