Abcam, ab223515, Anti-NPY6R antibody

Size: 50µL
Rabbit Polyclonal NPY6R antibody. Suitable for ICC/IF, IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NPY6R aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NPY6R aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q99463

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neuropeptide Y receptor type 6 (NPY6R) also called NPY6 receptor is a protein involved in signal transduction. It has a mass of roughly 50 kilodaltons. NPY6R is expressed in several tissues including the central nervous system and gastrointestinal tract. Researchers have identified its role in regulating physiological responses influenced by neuropeptide Y and peptide YY which are its primary ligands.
Biological function summary
NPY6R modulates appetite and energy balance. It forms part of a receptor complex that interacts with G-proteins to mediate its effects. By binding to its ligands it influences processes such as feeding behavior and gut functionality. NPY6R's activity regulates energy intake and may affect fat storage contributing to its biological functions.
Pathways
NPY6R plays a significant role in the neuropeptide Y signaling pathway and the hypothalamic-pituitary-adrenal (HPA) axis. These pathways manage stress response and energy homeostasis. NPY6R has interactions with other neuropeptide Y receptors such as NPY1R and NPY2R which collaborate in these metabolic and stress-related pathways.
NPY6R is associated with obesity and anxiety disorders. Its involvement in regulating appetite and energy balance links it to obesity research. Additionally alterations in NPY6R signaling may cause anxiety-related conditions with potential interactions involving corticotropin-releasing hormone receptor highlighting its broader impact on mental health pathways.