Abcam, ab223674, Anti-PTN antibody - C-terminal

Size: 100µg
Goat Polyclonal PTN antibody. C-terminal. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PTN aa 150 to C-terminus.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PTN aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P21246

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab223674 purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pleiotrophin also known as PTN Ptn or $Ptn is a heparin-binding growth factor with a molecular mass of approximately 18 kDa. It is expressed in various tissues notably in the brain during embryonic development and also in adulthood. PTN plays a fundamental role in cellular proliferation differentiation and survival. As a secreted protein it interacts with cell surface receptors to trigger intracellular signaling pathways.
Biological function summary
Pleiotrophin functions as a potent mitogen promoting cell growth and angiogenesis. It does not operate as part of a larger protein complex but acts independently to influence cellular behavior. Its interaction with receptor protein tyrosine phosphatase (RPTP) modulates the tyrosine phosphorylation state of other proteins affecting downstream signaling. This interaction facilitates communication between cells and their environments influencing development and tissue maintenance.
Pathways
This protein significantly impacts the PI3K/Akt and MAPK/ERK pathways key regulators of cell survival and proliferation. PTN often collaborates with proteins like Midkine (MK) due to their functional similarities and overlapping receptor targets. These pathways help regulate cellular responses to environmental cues contributing to processes such as tissue repair and regeneration.
The overexpression of pleiotrophin has been linked to the development of cancers such as breast cancer and glioblastoma. PTN's interaction with oncogenic pathways often involving proteins like N-cadherin enhances its relevance in tumor progression and metastasis. Additionally alterations in PTN expression or activity can influence neural disorders highlighting its importance in both oncological and neurological contexts.