Abcam, ab224034, Anti-XPNPEP2/mAPP antibody

Size: 100µL
Rabbit Polyclonal XPNPEP2/mAPP antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human XPNPEP2 aa 200-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human XPNPEP2 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.O43895

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
XPNPEP2 also known as membrane-bound aminopeptidase P or mAPP is an enzyme with a mass of approximately 74 kDa. This protein acts by cleaving the N-terminal amino acid from peptides where proline is the penultimate residue. It is an integral membrane protein mainly expressed in endothelial cells and is also detectable in the kidneys heart and liver. The primary function of XPNPEP2 involves peptide processing reflecting a specific enzymatic mechanism.
Biological function summary
This enzyme plays an important role in the degradation of bioactive peptides such as bradykinin. XPNPEP2 does not function as part of a larger protein complex but exhibits specific affinity toward substrates with proline residues. The enzymatic activity ensures the regulation of peptide hormones and other vasoactive compounds within the vascular system. Proper functioning of this target ensures balanced peptide levels affecting physiological processes primarily related to blood pressure regulation.
Pathways
The involvement of XPNPEP2 in the kallikrein-kinin system gives it a role in cardiovascular physiology. It interacts with proteins like kininogen and kallikrein which are critical components of this pathway. XPNPEP2 aids in modulating the activity of bradykinin a peptide known for its vasodilatory properties. Additionally the enzyme links to nitrogen metabolism sharing pathways with aminopeptidase families which are involved in metabolizing nitrogen-rich compounds.
Deficiencies or dysfunctions related to XPNPEP2 can contribute to conditions such as hereditary angioedema and hypertension. The relationship of XPNPEP2 with proteins like C1 inhibitor has implications in the former disease where improper regulation of vasoactive peptides leads to uncontrolled vascular permeability and swelling. In hypertension alterations in bradykinin metabolism caused by dysregulated XPNPEP2 activity may exacerbate or contribute to elevated blood pressure states. Understanding these interactions helps in identifying therapeutic targets for treatment and management.