Abcam, ab224085, Anti-SI antibody

Size: 100µL
Rabbit Polyclonal SI antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SI aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SI aa 1-200. The exact immunogen used to generate this antibody is proprietary information.P14410

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SI also known as sucrase-isomaltase is an enzyme complex with a molecular mass of approximately 245 kDa. It resides mainly in the brush border membrane of the small intestine. SI facilitates the digestion of dietary carbohydrates by splitting sucrose and isomaltase into simpler monosaccharides. This enzyme plays an important role in nutrient absorption and carbohydrate metabolism ensuring the small intestine can effectively process ingested sugars.
Biological function summary
SI serves as a critical mediator in carbohydrate metabolism. It consists of two subunits sucrase and isomaltase working in tandem to hydrolyze disaccharides. Each subunit contributes its specific catalytic activity to the breakdown of complex sugars. Enzymatic activity of SI is essential for the small intestine's ability to efficiently convert disaccharides into glucose and fructose. The localization of SI in the intestinal brush border maximizes its contact with ingested carbohydrates facilitating their rapid digestion and ensuing absorption.
Pathways
SI is integral to digestive pathways involving carbohydrate processing. It actively participates in the starch and sucrose metabolism pathway interacting with enzymes such as lactase and maltase which also hydrolyze carbohydrates. This connection underpins SI's contribution to the energy homeostasis by ensuring efficient carbohydrate digestion. Proper function of this pathway supports maintaining adequate glucose levels in the body highlighting its significant role in energy metabolism.
Mutations or deficiencies in SI lead to conditions like congenital sucrase-isomaltase deficiency (CSID) which results in carbohydrate malabsorption and gastrointestinal distress. Disorders related to SI often involve other proteins like lactase which also affect carbohydrate digestion. Understanding the relationship between SI and these digestive disorders aids in developing therapies and dietary adjustments aiming to alleviate symptoms associated with carbohydrate malabsorption.