Abcam, ab224594, Anti-PER3 antibody

Size: 50µL
Rabbit Polyclonal PER3 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PER3 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PER3 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.P56645

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PER3 protein also known as Period circadian protein homolog 3 plays an important role in maintaining the circadian rhythm. It has a molecular weight of approximately 126 kDa. PER3 is ubiquitously expressed with higher expression noted in tissues such as liver brain and heart. In particular its expression in the suprachiasmatic nucleus of the brain highlights its role in circadian regulation.
Biological function summary
PER3 contributes to the regulation of circadian rhythms and is a part of the circadian clock complex. Together with PER1 and PER2 PER3 participates in feedback loops that control transcriptional-translational cycles which impact various bodily functions such as sleep and metabolism. It binds with proteins like CRY1 CRY2 CLOCK and BMAL1 to establish and maintain the body's 24-hour cycle.
Pathways
PER3 integrates into the circadian rhythm signaling pathway. It interacts directly with other proteins like CLOCK and BMAL1 to modulate gene expression influencing sleep patterns hormonal control and metabolic processes. These interactions highlight its essential role in maintaining homeostasis within the circadian clock machinery and its impact on the sleep-wake cycle.
PER3's dysfunction associates with sleep disorders and certain mood disorders. Variants in the PER3 gene have shown links to delayed sleep phase disorder and bipolar disorder. Additionally PER3's interaction with other proteins such as PER1 and PER2 plays a significant role in these pathways indicating how disturbances in these interactions can lead to circadian-related pathologies.