Abcam, ab224728, Anti-Gpihbp1 antibody

Size: 50µL
Rabbit Polyclonal Gpihbp1 antibody. Suitable for WB, IHC-P and reacts with Rat, Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GPIHBP1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human GPIHBP1.Q8IV16

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Gpihbp1 also known as GPIHBP1 is a glycosylphosphatidylinositol-anchored protein that plays a mechanical role in transporting lipoprotein lipase (LPL) to the capillary lumen. This protein has a molecular weight of about 20 kDa. GPIHBP1 is expressed mainly in the endothelial cells of capillaries within adipose tissue heart and skeletal muscle. It binds with LPL and anchors it to the endothelial cell surface facilitating the hydrolysis of triglycerides in circulating chylomicrons and very-low-density lipoproteins.
Biological function summary
The presence of GPIHBP1 is essential for the proper functioning of the lipolysis process enabling the breakdown of triglycerides into free fatty acids and glycerol. It forms a stable complex with LPL that is necessary for LPL's movement from interstitial spaces to the luminal surface of capillaries. Without this function the processing of lipid particles in the bloodstream would be disrupted affecting the availability of free fatty acids for uptake by tissues.
Pathways
GPIHBP1 participates significantly in the lipid metabolism pathway specifically concerning the regulation of plasma triglyceride levels. This pathway includes key interactions with other proteins such as chylomicrons which it assists in metabolizing and apolipoprotein C-II a cofactor required for LPL activity. GPIHBP1 ensures that LPL is correctly localized to execute its function in hydrolyzing triglycerides in these pathways.
Dysfunction or deficiency of GPIHBP1 can result in severe hypertriglyceridemia a condition linked to an increased risk of pancreatitis. Mutations affecting GPIHBP1 can impair LPL function leading to the accumulation of triglyceride-rich lipoproteins in the bloodstream which can potentially cause acute pancreatitis. The protein also indirectly connects to Apolipoprotein C-II through its role in LPL regulation as both are critical for lipid metabolism and energy homeostasis.