Abcam, ab225234, PE Anti-IGBP1 antibody [EPR12315]

Size: 100µL
Rabbit Recombinant Monoclonal IGBP1 antibody - conjugated to PE. Suitable for Flow Cyt (Intra) and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR12315,
Isotype:IgG,
Conjugation:PE,
Excitation/Emission:Ex: 480;565nm, Em: 578nm,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Do Not Freeze, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Insulin-like Growth Factor Binding Protein 1 (IGBP1) is a multifunctional protein involved in various cellular processes. It is also known as IGFBP-1 and has a molecular mass of approximately 31 kDa. IGBP1 is widely expressed in human tissues with higher levels detected in the liver and the endometrium. The protein plays a role in modulating the availability of insulin-like growth factors (IGFs) by binding to them affecting their function and stability within the body.
Biological function summary
Many cellular processes involve IGBP1 as it binds with insulin-like growth factors to modulate their actions effectively acting as a regulator within the IGF system. IGBP1 may influence cell growth survival and metabolism. It often interacts with other proteins within an IGF-binding complex allowing it to perform various regulatory functions that impact both normal and pathological conditions.
Pathways
Several signaling pathways incorporate the activities of IGBP1 particularly the insulin-like growth factor signaling pathway and the PI3K/AKT pathway. IGBP1 interacts with other proteins such as IGF1R and IRS-1 affecting downstream signaling that governs aspects of cell proliferation and survival. These interactions position IGBP1 as an important regulatory molecule in these pathways influencing cellular responses to IGFs.
Research has linked abnormal levels or activities of IGBP1 with conditions such as diabetes and cancer. IGBP1's modulation of the insulin-like growth factors may affect insulin sensitivity and glucose metabolism contributing to diabetes pathogenesis. In cancer altered IGBP1 expression can influence tumor growth and progression where its relationship with IGF1 and IGF2 is significant in the context of growth factors and their signaling pathways.